Enhancing full-length antibody production by signal peptide engineering
نویسندگان
چکیده
منابع مشابه
Enhancing full-length antibody production by signal peptide engineering.
BACKGROUND Protein secretion to the periplasm of Escherichia coli offers an attractive route for producing heterologous proteins including antibodies. In this approach, a signal peptide is fused to the N-terminus of the heterologous protein. The signal peptide mediates translocation of the heterologous protein from the cytoplasm to the periplasm and is cleaved during the translocation process. ...
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ژورنال
عنوان ژورنال: Microbial Cell Factories
سال: 2016
ISSN: 1475-2859
DOI: 10.1186/s12934-016-0445-3